Tiapride Associated Toxic Epidermal Necrolysis in an HIV-Infected Patient
نویسندگان
چکیده
Toxic epidermal necrolysis (TEN) is a severe adverse cutaneous drug reaction characterized by mucosal erosion and epidermal detachment [1]. It is usually distinguished from Stevens-Johnson Syndrome (SJS) by the extent of affected body surface area (BSA): SJS when less than 10% of BSA is affected, TEN when BSA affected is more than 30% and when 10 to 30% of BSA is affected as SJS-TEN overlap [1,2]. TEN is a rare condition, with an estimated incidence of 0.4 to 1.9 per million people annually [3-5]. Reported incidence in HIV infected patients is higher, as much as 1 per 1000 people annually [6]. Some of the most frequently implicated drugs are anti-infective sulfonamides, phenytoin, carbamazepine, phenobarbital and allopurinol [7]. We present the first reported case of TEN attributable to tiapride, a neuroleptic drug mainly used in alcoholic withdrawal syndrome.
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